Benetton Treviso centre Tommaso Benvenuti will make his international debut for Italy when they face Argentina in Verona on Saturday.
The 19-year-old has been in terrific form for the Magners League new-boys so far this season and will make his bow on the wing for his nation.
Stade Francais No8 Sergio Parisse returns from a neck injury to captain the side from the back-row.
Following the Argentina clash Italy travel south to Florence when they host Australia a week later before rounding off their November internationals against Fiji.
Italy: 15 Luke McLean, 14 Tommaso Benvenuti , 13 Gonzalo Canale, 12 Andrea Masi, 11 Mirco Bergamasco, 10 Craig Gower, 9 Tito Tebaldi, 8 Sergio Parisse (c), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Quintin Geldenhuys, 4 Carlo Antonio Del Fava, 3 Martin Castrogiovanni, 2 Leonardo Ghiraldini, 1 Salvatore Perugini.
Replacements: 16 Fabio Ongaro, 17 Andrea Lo Cicero, 18 Santiago Dellape', 19 Paul Derbyshire, 20 Pablo Canavosio, 21 Luciano Orquera, 22 Alberto Sgarbi.
Date: Saturday, November 13
Venue: Stadio Marcantonio Bentegodi, Verona
Kick-off: 15.00 (14.00 GMT)
Referee: Chris Pollock (New Zealand)