Scotland head coach Andy Robinson has requested five members of his current Scotland squad play no more club rugby until the end of the season.
Edinburgh's Allan Jacobsen and Ross Ford and Glasgow Warriors' Richie Gray, John Barclay and Alastair Kellock are all to be rested.
Warriors coach Sean Lineen and Edinburgh counterpart Nick Scrivener have been consulted about the decision.
"It's based on individual players and their programmes," said Robinson.
"This is a decision that's not been taken lightly.
"It's a reflection on the season and the previous seasons they've had and it's done on an individual basis.
"Richie Gray has doubled his game time this year and he has performed at a higher level of match as well and performed outstandingly well.
"This is for his development for the World Cup, but also for future matches – it's looking ahead to two, three years time as well.
"(Ford and Jacobsen) have had high game time in the previous three years. They've played a lot of rugby and they've had high game time this year.
"We feel it's in the best interests for their development and for the Rugby World Cup that they are made unavailable for Edinburgh now."
"They (Scrivener and Lineen) were disappointed and naturally disappointed, because they want their players to play for the club, but they understood.
"Post-World Cup, I believe you're going to get a better player coming back ready to play for the pro teams."