Damien Hoyland returns from injury to start on the right wing, with Sam Beard also back in the starting line-up at inside centre with Andries Strauss and Chris Dean both out injured.
In the pack, a new look second-row pairing of Ben Toolis and Anton Bresler start with captain Mike Coman returning to blindside flanker after featuring as a lock against Cardiff Blues in their last GUINNESS PRO 12 outing.
Edinburgh currently sit fifth in the table on 37 points, with Scarlets three points and three positions ahead in second.
"The Scarlets at home is always incredibly tough and we will need to improve considerably from our Cardiff performance to get a result," said Solomons.
The previous two meetings between the two sides ended as a 20-all draw at BT Murrayfield and a 26-15 victory for Edinburgh at Parc Y Scarlets in March, which brought an end to an impressive home record from the Scarlets.
Edinburgh have struggled to find wins whilst on their travels to Wales, with that victory in March being their only win in the last five trips.
And although Edinburgh will be without key forwards WP Nel, Ross Ford, Alasdair Dickinson, John Hardie and Stuart McInally, Scarlets prop Phil John is still expecting a tough battle up front.
He said: "It will probably be a forwards dominated game against Edinburgh. It's likely to be a tough up front battle.
"We'll work hard as a forwards unit; work hard on things that didn't work so well for us in the last game.
"The conditions will probably be against us and not allow us to play the type of rugby we want to."
South African lock David Bulbring is in the starting line-up to make his Scarlets debut, and scrum-half Aled Davies has been released from the Welsh camp to take his place on the substitute's bench as Bristol-bound Rhodri Williams is set to make his 100th appearance for the club.
Wayne Pivac's side have lost three of their last four league matches that has seen them surrender their top spot to Irish outfit Ulster, and there are currently just five points separating the top five teams in the GUINNESS PRO12 league table.
However, the Scarlets' home form has been excellent, with them losing just one of their last eight league games on home soil, which was a 26-27 Boxing Day defeat to fellow Welsh side the Ospreys.
But John is not underestimating the threat that Edinburgh will pose on Friday evening.
"There's some pressure on ourselves now with the latest results going against us. It'll be a shame to let that slip. We will take every game week by week and try and stay in the top four," added John, who will start as loosehead prop against Edinburgh.
"So many teams are capable of wins that can put them into the top four. To have results against teams in the top six or seven over the next few weeks would be massive."
At Parc y Scarlets, 8.15pm. Live on BBC Wales/BBC Sport Scotland
Referee: Andrew Brace (IRFU, 8th competition game)
Assistant Referees: Craig Evans, Greg Morgan (both WRU)
Citing Commissioner: Dennis Jones (WRU)
TMO: Jon Mason (WRU)
1st Floor Simmonscourt House
Ballsbridge, Dublin 4, Ireland