Edinburgh welcomed back international front-row trio of Allan Jacobsen, Ross Ford and Geoff Cross and the stability upfront seemed to work wonders as the Scots raced into a 21-0 lead after just 17 minutes.
After missing an early strike at goal through Greig Laidlaw - three tries in nine minutes from David Denton and a double from Tim Visser effectively ended the contest before a quarter of the game had even elapsed.
Inside ten minutes Nick De Luca recycled the ball for Edinburgh, allowing Denton to crash over - Laidlaw kicked the extras.
And it was 14-0 just minutes later as once again De Luca was the provider for Edinburgh, crashing through the Aironi defence before offloading to Visser.
Edinburgh's dominance upfront was confirmed on 17 minutes as the Aironi scrum creaked and off first-phase ball - Visser scored a cracking try - his second of the evening.
Aironi briefly looked as though they would get a foothold in the game as Scotland-born George Biagi charged down a kick and scored under the post but normal service was shortly after for Edinburgh.
Just five minutes later Laidlaw extended Edinburgh's lead to 24-5 with a penalty, before De Luca added his side's fourth try of the evening under the posts, finishing off a fine move following lovely hands by Sean Cox.
Edinburgh's relentless charge towards the win was briefly halted just before half-time when try-scorer Denton was yellow carded for an infringement but Aironi's comeback hopes were short-lived.
Despite the withdrawal of the impressive De Luca at the break - Edinburgh dominated the early exchanges of the second-half, dominating territory.
And on 52 minutes they won a scrum against the head and after recycling the ball, it was worked out to Visser who darted over for his third try of the game.
Lee Jones was the next man to go for Edinburgh, collecting a perfectly weighted kick from Phil Godman to go over - unfortunately the latter couldn't add the extras.
Chris Leck brought up the half century with Edinburgh's seventh score of the night, while Aironi added a late consolation score from Filippo Ferrarinni but it was a chastening experience for the visitors.
|Edinburgh Rugby Score Card|
|Nick de Luca||1||5|
|Aironi Rugby Score Card|
|George Fabio Biagi||1||5|