Brett Wilkinson, Adrian Flavin and Ronan Loughney make up the front row trio with a total tally of 429 Connacht caps between them.
21-year-old Kieran Marmion, who has started every game this season, remains in the half back pairing with Dan Parks.
March 'Player of the Month' Brian Murphy is named at first centre for his fifth Connacht start this year.
Earlier in the week, Head Coach Eric Elwood spoke about the upcoming game:
"We were obviously happy with last week's win against Edinburgh. It was a very good victory for us but we're not getting carried as it means nothing if we can't back it up and have consistency now in this derby match against Ulster.
"We have a point to prove in that were nilled up in Belfast and that's a big incentive. We were disappointed with our away performances in the derby fixtures so we have another opportunity for four points here.
"We're looking forward to a physical contest. You can't shy away from the physicality. You have to be able to go toe-to-toe up front with Ulster and you have to be able to control the break down area. And that's key for us this weekend.
"We'll have the extra spice of the derby game at home. They're looking for top four and we still believe we have a lot to play for with three to go. So it should be ding dong."
15. Robbie Henshaw
14. Danie Poolman
13. Eoin Griffin
12. Brian Murphy
11. Gavin Duffy (captain)
10. Dan Parks
9. Kieran Marmion
1. Brett Wilkinson
2. Adrian Flavin
3. Ronan Loughney
4. Michael Swift
5. Mike McCarthy
6. Mick Kearney
7. John Muldoon
8. George Naoupu
Replacements: Ethienne Reynecke, Rodney Ah You, JP Cooney, Andrew Browne, Mata Fifita, Paul O'Donohoe, Miah Nikora, Fetu'u Vainikolo
Unavailable due to injury: Denis Buckley, Willie Faloon, Eoghan Grace, Jason Harris-Wright, Johnny O'Connor, Eoin McKeon, Dave McSharry, Frank Murphy, Dave Nolan, Kyle Tonetti, Nathan White.
Connacht Rugby v Ulster Rugby
At Sportsground , 7.45pm.
Live on TG4 and BBC Sport Northern Ireland
Referee: Peter Fitzgibbon (IRFU, 47th competition game)
Assistant Referees: Leo Colgan, B O'Connell (both IRFU)
Citing Commissioner: Eugene Ryan (IRFU)
TMO: Seamus Flannery (IRFU)