Connacht Rugby travel across the country to Dublin this weekend to play provincial rivals Leinster in Round 6 of the RaboDirect PRO12.
There are three changes to the team that defeated Zebre 33 - 6 in last week's Heineken Cup encounter.
Danie Poolman, who was forced to withdraw late this week due to a tight hamstring, is replaced on the right wing by Tiernan O'Halloran. Mayo-man Gavin Duffy returns to full back, replacing the injured James So'oialo.
Up front, Andrew Browne moves to the bench and makes way for last week's try scorer Mata Fifita at blindside flanker.
On the bench, hooker Dave Heffernan is in line to make his first senior appearance in the number 2 jersey. Utility back Daragh Leader is another addition to the match day squad. The 20-year-old from Galway made his first senior appearance away to Ospreys this time last year.
Head Coach Pat Lam commented on the team selection and the upcoming game:
"It's been a pretty disruptive week with injuries and we've lost more players with none coming back into the frame. So once again, we've had to dig deep into our resources
"With James and Danie injured in the backs, we've lost our cover at outside centre. And so young Daragh Leader comes on to the bench after impressing for the Eagles last weekend. He's been a big part of our training squad in recent weeks.
"Up front, Mata replaces Andrew Browne at six. Browney was unable to train fully this week due to a few knocks he picked up in the last game. But thankfully, with all the injuries we have to the back row, he recovered sufficiently to take his place on the bench.
"Dave Heffernan comes in as cover for hooker and this is a huge opportunity for him to make his mark.
"Coming up against Leinster at the RDS - it doesn't get much bigger than that. The current Rabo champions, they've been consistently the best team in Europe for the last number of years. Full of internationals, we know their players will be out to stake a claim ahead of the November series. We know what we're up against.
"But these are the type of games you relish and we can't wait for the challenge. We have trained well on the back of a good win in the Heineken Cup and of course we have a plan to execute in order to give us the best opportunity to beat this team."
Connacht line-up v Leinster
15. Gavin Duffy
14. Tiernan O'Halloran
13. Robbie Henshaw
12. Craig Ronaldson
11. Matt Healy
10. Dan Parks
9. Kieran Marmion
1. Brett Wilkinson
2. Sean Henry
3. Rodney Ah You
4. Michael Swift (captain)
5. Craig Clarke
6. Mata Fifita
7. Jake Heenan
8. George Naoupu
16. Dave Heffernan
17. JP Cooney
18. Ronan Loughney
19. Aly Muldowney
20. Andrew Browne
21. Paul O'Donohoe
22. Darragh Leader
23. Fionn Carr
Unavailable/Injured: Willie Faloon, Conor Finn, Eoin Griffin, Jason Harris-Wright, Eoin McKeon, Shane Layden, John Muldoon, Miah Nikora, Danie Poolman, Peter Reilly, James So'oialo, Kyle Tonetti, and Nathan White